Cart
sales@molnova.com
Epimedokoreanin B
CAS No. 161068-53-7
Epimedokoreanin B( —— )
Catalog No. M37770 CAS No. 161068-53-7
Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 298 | Get Quote |
|
| 5MG | 472 | Get Quote |
|
| 10MG | 687 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameEpimedokoreanin B
-
NoteResearch use only, not for human use.
-
Brief DescriptionEpimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.
-
DescriptionEpimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.
-
In VitroCell Cytotoxicity AssayCell Line:A549, Calu1 and H1299 cells Concentration:3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM Incubation Time:48 hours Result:Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.Western Blot Analysis Cell Line:Human monocyte-derived macrophages (HMDMs) Concentration:5 μM Incubation Time:24 hoursResult: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.
-
In VivoAnimal Model:Female C3H mice (8-10 weeks old) injected with LM8 cells Dosage:20 mg/kg Administration:Oral administration; thrice a week; for 17 days Result:Inhibited tumor growth.
-
Synonyms——
-
PathwayApoptosis
-
TargetApoptosis
-
RecptorApoptosis | Antibacterial
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number161068-53-7
-
Formula Weight422.47
-
Molecular FormulaC25H26O6
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(C=C(C)C)C1=C2C(C(=O)C=C(O2)C3=CC(CC=C(C)C)=C(O)C(O)=C3)=C(O)C=C1O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Huaran Zhang, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020 May;34(9):1256-1263.?
molnova catalog
related products
-
Bigelovin
Bigelovin is a selective retinoid X receptor α agonist.?Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a potent cytotoxic sesquiterpene lactone from Inula sp.
-
Cholesteryl Hemisucc...
Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties.
-
TVB-3166
TVB-3166 induces apoptosis and inhibits in-vivo xenograft tumor growth. TVB-3166 is a reversible and selective fatty acid synthase inhibitor (IC50s: 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis, respectively).
