Epimedokoreanin B( —— )

Catalog No. M37770 CAS No. 161068-53-7

Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Epimedokoreanin B
Note

Research use only, not for human use.
Brief Description

Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.
Description

Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.
In Vitro

Cell Cytotoxicity AssayCell Line:A549, Calu1 and H1299 cells Concentration:3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM Incubation Time:48 hours Result:Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.Western Blot Analysis Cell Line:Human monocyte-derived macrophages (HMDMs) Concentration:5 μM Incubation Time:24 hoursResult: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.
In Vivo

Animal Model:Female C3H mice (8-10 weeks old) injected with LM8 cells Dosage:20 mg/kg Administration:Oral administration; thrice a week; for 17 days Result:Inhibited tumor growth.
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis | Antibacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

161068-53-7
Formula Weight

422.47
Molecular Formula

C25H26O6
Purity

>98% (HPLC)
Solubility

——
SMILES

C(C=C(C)C)C1=C2C(C(=O)C=C(O2)C3=CC(CC=C(C)C)=C(O)C(O)=C3)=C(O)C=C1O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Huaran Zhang, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020 May;34(9):1256-1263.?

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