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Epimedokoreanin B

CAS No. 161068-53-7

Epimedokoreanin B( —— )

Catalog No. M37770 CAS No. 161068-53-7

Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Epimedokoreanin B
  • Note
    Research use only, not for human use.
  • Brief Description
    Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.
  • Description
    Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.
  • In Vitro
    Cell Cytotoxicity AssayCell Line:A549, Calu1 and H1299 cells Concentration:3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM Incubation Time:48 hours Result:Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.Western Blot Analysis Cell Line:Human monocyte-derived macrophages (HMDMs) Concentration:5 μM Incubation Time:24 hoursResult: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.
  • In Vivo
    Animal Model:Female C3H mice (8-10 weeks old) injected with LM8 cells Dosage:20 mg/kg Administration:Oral administration; thrice a week; for 17 days Result:Inhibited tumor growth.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    161068-53-7
  • Formula Weight
    422.47
  • Molecular Formula
    C25H26O6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(C=C(C)C)C1=C2C(C(=O)C=C(O2)C3=CC(CC=C(C)C)=C(O)C(O)=C3)=C(O)C=C1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Huaran Zhang, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020 May;34(9):1256-1263.?
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